P R E M A R IN V a g in a l C r e a m r e s t o r e s v a g in a l t is s u e s a f t e r m e n o p a u s e , to h e lp r e lie v e d r y n e s s a n d

e v e n p a in fu l in t e r c o u r s e .

If you’ve gone through menopause and are experiencing vaginal dryness and discomfort, you might want to learn

more about PREMARIN Vaginal Cream. Menopause can cause changes in vaginal tissue, resulting in uncomfortable symptoms. PREMARIN Vaginal Cream

treats the underlying cause of these symptoms and can restore the tissues that provide elasticity and lubrication. And you don’t need to keep using it forever;

just as long as you need treatment.

Im p o rtan t S a fe ty In fo rm atio n

What is the most important information you should know about PREMARIN Vaginal Cream (an estrogen mixture)?

• Estrogens may increase the chance of getting cancer of the uterus. Report any unusual vaginal bleeding right away while you are using

PREMARIN Vaginal Cream. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your health care provider

should check any unusual vaginal bleeding to find out the cause.

• Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia. Using estrogens, with or without

progestins, may increase your chance of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogens, with or without progestins,

may increase your chance of getting dementia, based on a study of women age 65 years or older. You and your health care provider should talk

regularly about whether you still need treatment with PREMARIN Vaginal Cream.

PREMARIN Vaginal Cream is used after menopause to treat menopausal changes in and around the vagina and painful intercourse caused by these changes.

PREMARIN Vaginal Cream should not be used if you have unusual vaginal bleeding, have or had cancer of the breast or uterus, had a stroke or heart

attack, have or had blood clots or liver problems, are allergic to any of its ingredients, or think you may be pregnant. Most common side effects include

headache, infection, abdominal pain, back pain, accidental injury, and vaginitis.

Please see Patient Information inside. You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

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